Endocrine Abstracts

Introduction: 3-Iodothyronamine (T1AM) is a novel endogenous relative of thyroid hormone able to interact with specific G protein-coupled receptors, known as trace amine-associated receptors (TAAR). Metabolic, endocrine and cardiac effects of exogenous T1AM have been reported.Methods: We synthesized radiolabelled T1AM, [125I]-T1AM, and explored its distribution in different mouse organs after injection in the tail vein. The specificity of [<su...

3-iodothyronamine (T1AM) is an endogenous thyroid hormone derivative which produces profound metabolic effects such as a shift in fuel substrate utilization from carbohydrates to lipid. Thus, in the present work we investigated the effects of T1AM on hepatic glucose metabolism.To assess metabolite release, human hepatocellular carcinoma cells (HepG2) were exposed for 4 h to different concentrations of exogenous T1AM (0.1, 1 and 10 μM) in glucose pro...